Two major types of MAD were differentiated according to body fat distribution patterns and were linked to different genetic defects: type A (MADA; OMIM #248370), characterized by a partial form of lipodystrophy, caused by pathogenic variants in the LMNA gene encoding lamin A/C [2]; and type B (MADB; OMIM #608612), presenting with generalized lipodystrophy, caused by molecular defects in the zinc metalloproteinase (ZMPSTE24) gene [3]. The gene discussed is LMNA; the disease is generalized lipodystrophy.