LMNA and laminopathy: Mutations in LMNA give rise to very diverse clinical phenotypes collectively called “primary laminopathies” that include skeletal myopathies such as Emery–Dreifuss muscular dystrophy and limb–girdle muscular dystrophy, premature aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS), restrictive dermopathy, and mandibulo acral dysplasia, as well as isolated cardiac disease with arrhythmia and dilated cardiomyopathy with conduction system disease [5].