We believe that the measure of TFF2/TFF2/Tff2 expression level in response to HFD could expand our cellular and molecular understanding of obesity and strengthen therapeutic research especially that TFF2 could be a lipid-specifically induced signal we are yet to confirm to complete the puzzle of fat-induced signals, appetite control and adiposity storage; all key elements in energy homeostasis and obesity development. The gene discussed is TFF2; the disease is obesity due to melanocortin 4 receptor deficiency.