Therefore, HFD would induces its overexpression to facilitate the digestion and the anabolism of lipids coming from such HFD, whereas Tff2 KO would deprive the metabolic machinery from molecular tools required to use the ingested lipids through an increased lipid absorption and storage, which leads to a protection from the HFD-induced obesity. This evidence concerns the gene TFF2 and obesity due to melanocortin 4 receptor deficiency.