On the same chromosome, two significant SNPs (AX-106741653 and AX-115114947) in the RB breed were located close to the AKAP8 gene, which was associated with somatic cell count in seven different populations of dairy cows in a complex study that used the combined approach of examining previous results from differential gene expression analysis and GWAS studies to identify the key pathways and candidate genes that potentially confer genetic resistance to mastitis in dairy cows [48]. Here, AKAP8 is linked to mastitis.