Fresh frozen plasma may be used for dogs with either hemophilia A or B, but due to the different sizes of FVIII and FIX proteins, cryo-poor plasma should be administered to dogs with hemophilia B, while cryoprecipitate should be used for hemophilia A. Canine cryo-poor plasma, which is rich in smaller proteins such as FIX, is considerably less expensive than fresh frozen plasma and is preferred for hemophilia B patients, when available [3,30,31]. The gene discussed is F8; the disease is hemophilia A.