For example, the prospective cohort studies from the International BRCA1/2 Carrier Cohort Study (IBCCS), Breast Cancer Family Registry (BCFR), and Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer (kConFab) suggest that both family history and variant location in the gene influence cancer risk [58,59,60]. The gene discussed is BRCA1; the disease is breast cancer.