RNF213 and Crouzon syndrome-acanthosis nigricans syndrome: With respect to the ICAN group, no significant differences were observed between patients with and without the RNF213 (c.14576G>A) mutation in all respects, including age, sex, past medical history, smoking history, family history of CAN, ruptured or unruptured ICAN, bilaterality, multiplicity, and location.