Interestingly, the patients display different clinical phenotypes, and among this small group of LDS4/TGFB2 patients, our patient is the only one displaying aortic/arteries ectasia or aneurysm, while one patient had type B aortic dissection (Table 2 This result changed the clinical diagnosis of the propositus (Figure 1, II-2). This evidence concerns the gene TGFB2 and Aortic dissection.