The independent predictors of mortality among the studied cohort of severe COVID-19 cases were: treatment modality (lowest mortality and long overall survival [OS] in group C); history of comorbid diseases (DM, MI, CKD, COPD, asthma, and lung fibrosis), increased CRP and NLR; and longer hospital, IC, and MV stay. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.