A study demonstrated that HCC development in CHC-infected patients following a SVR depended on age (≥55) (p = 0.021), hepatic fibrosis (F3–4) (p = 0.0028), and hepatic steatosis (grade 2–3) (p = 0.0002) at pre-IFN treatment, where HCC developed within a period of 10 years. This evidence concerns the gene IFNA1 and fatty liver disease.