Only the percentages of TIM3 and CTLA-4 expression on CD4+ cells (TIM3+CD4+ and CTLA-4+CD4+), CTLA-4+CD8+ and TIM3+ monocytes were significantly higher in the LTBI-ESRD group than in the LTBI-non-CKD group (Figure 1). The gene discussed is CD8A; the disease is chronic kidney disease.