Moreover, this polyphenol promoted apoptosis in HCT116, HT29, and SW620 colorectal cancer cell lines by suppressing constitutive and inducible NF-kB activity and NF-kB-regulated gene products such as Bcl-2, Bcl-xL, IAP-2, COX2 and cyclin D1 [86]. The gene discussed is NFKB1; the disease is colorectal cancer.