Rankin et al. reported that the difference in mRNA and cytoplasmic protein levels of survivin between MIUC samples and healthy controls did not reach statistical significance (p = 0.06 and p = 0.07 respectively) [61], However, 68% of MIUC samples had nuclear survivin localization that was not detected in any of the normal bladder tissue samples (p < 0.001), supporting the immunohistochemical studies in human BlCa [63]. The gene discussed is BIRC5; the disease is bladder transitional cell carcinoma.