ACTA2 and systemic sclerosis: Transfection of miR-29b-3p, miR-138-5p, and miR-146b-5p in both IPF and SSc pulmonary fibroblasts resulted in downregulation of several profibrotic genes, COL1A1 (miR-29b-3p target gene), connective tissue growth factor (CTGF; miR138-5p target gene), and actin alpha 2 (ACTA2; miR-146b-5p target gene) [97].