Some previous studies on miRNAs and hub genes involved in CRC identified 10 hub genes, SLC26A3, CLCA1, CLCA4, GUCA2A, GUCA2B, MS4A12, KRT20, AQP8, MAOA, and ADH1A, four differentially expressed miRNAs, miR-423-5p, miR-552, miR-502-3p, and miR-490-5p [75], and a specific miRNA and its role in CRC by targeting specific hub genes [76,77,78,79]. This evidence concerns the gene CLCA4 and colorectal carcinoma.