Both turned out to be highest for hyperglycemia/hyperinsulinemia (obese diabetic ZDF rats), lowest for normoglycemia/normoinsulinemia (lean Wistar rats), and intermediary for normoglycemia/hyperinsulinemia depending on the plasma insulin level (Table 2) with the following ranking order of declining efficacy/inhibition: Obese ZF rats > obese Wistar > lean ZDF > lean ZF (Figure 7b and Figure 12b). Here, INS is linked to hyperinsulinism.