The major hallmarks of AD are the increase in amyloid-β precursor protein (APP), the deposition of amyloid-β (Aβ) plaques and α-synuclein (α-Syn), the activation of astrocytes/microglia, the hyperphosphorylation and aggregation of tau, neuroinflammation and the cell death of neurons [81,82,83]. Here, MAPT is linked to Alzheimer disease.