Furthermore, the PPI network illustrated that the genes CTNNB1 (β-catenin), CEBPD (CCAAT enhancer binding protein delta), and EDN1 (endothelin 1) were involved in CXCL8 and SRC interactions, promoting HCC progression (p = 0.0394) (Figure 6A). Here, CTNNB1 is linked to hepatocellular carcinoma.