Comparisons of mRNA levels at three time points of ischemic stroke revealed that TPH1 expression was significantly lower in the acute phase following thrombolysis (fold change ‘B’: 0.89) compared to both before (fold change ‘A’: 1.12) and following >10 h (fold change ‘C’: 0.97) the treatment (p = 0.0013 and 0.039, respectively) (Figure 5a). This evidence concerns the gene TPH1 and ischemic stroke.