IDO1 and small vessel stroke: Similarly to as seen in the case of the rs10089084 IDO1 variant, the rs7820268 SNP was also significantly more frequent in the recessive model (TT vs. TC + CC) among patients with TOAST classification of ‘small vessel stroke’ and ‘cardioembolic stroke’ compared to control individuals (TT (Str ‘small vessel’): 21.62% and TT (Str ‘cardioembolic’): 22.72% vs. TT (Ctr total): 8.33 %; p = 0.027 and 0.043, respectively) (Figure 3C(c)).