SHMT2 and metabolic dysfunction-associated steatotic liver disease: Taking into account the aforementioned findings [71], in the present study, the increased expression of key genes involved in folate metabolism (SHMT2, MTHFD1, DMGDH, SARDH, and GNMT) and in the transsulfuration pathway (CBS and CTH) found in the livers of CMA-supplemented hamsters strongly suggests that CMA ameliorated NAFLD promoting glutathione biosynthesis through the activation of these two metabolic pathways.