A recent study by Cochrane et al. proposed that clear-cell and endometrioid carcinomas may originate from different cell types of endometria as clear-cell tumors express much higher level of markers of the ciliated cells (cystathionine gamma-lyase (CTH), etc.), while endometrioid tumors express markers of the secretory cells of the endometrium (methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and ER) [22]. The gene discussed is CTH; the disease is endometrioid adenocarcinoma.