The results obtained using a HypoxiSenseTM-680 fluorescent imaging agent that detects carbonic anhydrase 9 (CA IX) tumor cell surface expression revealed a rise of hypoxia in shLRP-1 tumors compared to shCtrl (0.079 ± 0.020 vs. 0.010 ± 0.04 pmol/mm3) (Figure 2D). The gene discussed is CA9; the disease is neoplasm.