CCND1 and renal cell carcinoma: Importantly, upon revision, seven tumors (4.5% of pRCCs) were identified that had a biphasic appearance, containing glomerular/alveolar structures lined by small cells with low nuclear grade, with squamoid-like larger cells in the center, with higher nuclear grade and specifically expressing nuclear cyclinD1; these were regarded as BSA RCC (Figure 4).