As adropin reverses this phenotype in skeletal muscle of ex vivo hearts from lean non-fasting mice and diet-induced obesity mice, and as adropin levels are significantly lower in patients with DM, it is plausible that stimulation of adropin pathways could mitigate the detrimental effects of this lethal DM complication [3,17]. This evidence concerns the gene ENHO and obesity due to melanocortin 4 receptor deficiency.