Specifically, in a study by Wu et al., adropin was inversely and independently associated with the angiographic severity of coronary atherosclerosis, whereas adropin levels were significantly lower in patients with AMI compared with controls or patients with stable angina pectoris in a study by Yu et al. In line with this, Celik et al. reported that lower adropin levels are an independent risk factor of cardiac syndrome X, a distinctive clinical form of microvascular dysfunction [48]. This evidence concerns the gene ENHO and coronary atherosclerosis.