To extend our knowledge of the specific expression of eight proteins in a prostate cancer cell with amphicrine features, like VCaP, we determined the endogenous expression level of proteins in five different prostate cancer cell lines from the Dependency Map portal (https://depmap.org, accessed on 7 September 2021) along with the expression of AR and neuroendocrine biomarker, synaptophysin (SYP), which shows an amphicrine feature [36]. The gene discussed is SYP; the disease is prostate cancer.