LDHB and neoplasm: Although the absence of the LDHB was not found in LNCaP but in LNCaP-LN3 cells at the protein and mRNA level [70], and the loss of LDHB increased the tumorigenicity of prostate cancer cells [71], it has been shown that increased LDHB activity and the Warburg effect are required for tumor progression and metastases in a preclinical model of prostate cancer [72].