A report by Ji et al. sheds light on the complicated crosstalk between p53 and TGF-β, where, using non-small-cell lung carcinoma (H1299) and mouse oral cancer-derived (J4708) cells (both p53-/-), it was demonstrated that transfection of mutant p53 (R175H) binds to the MH2 domain in SMAD3, which led to the disruption of the formation of the SMAD3–4 complex [36]. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.