Previous studies showed that the somatic mutations of ovarian clear cell carcinoma (mainly in ARID1A, PIK3CA, KRAS and PPP2R1A) might be related to chromatin remodeling, cell proliferation, cell cycle checkpointing and cytoskeletal organization [39,40,41,42,43,44,45,46,47,48,49]. This evidence concerns the gene PIK3CA and ovarian clear cell cancer.