Other infrequent gene mutations of clear cell carcinoma included ARID1B, ARID3A, CREBBP, CSMD3, CTNNB1, LPHN3, LRP1B, MAGEE1, MLH1, MLL3, MUC4, PIK3R1, PTEN and TP53 [41,43,46,48,49]. The gene discussed is PIK3R1; the disease is clear cell adenocarcinoma.