In line with this, BRCA1, p19Arf, and p53 genes in MCF-7 breast cancer cells; MTS1, p19Arf, and p53 genes in B16-F0 melanoma, and Dmp1, p21, and BCl2 genes in EAC cell lines are among significantly upregulated tumor suppressor genes. The gene discussed is DMP1; the disease is melanoma.