Genes such as PTEN, a positive regulator p53 [79]; BRCA1, a co-activator of p53 [80,81]; and Dmp1, a transcription factor that interacts directly with p53 [82] are upregulated in 3-MBTSc and 4-NBTSc treated tumor cells than untreated. The gene discussed is PTEN; the disease is neoplasm.