In follicular thyroid cancer aggressive tumors, along with high expression of osteopontin, increased levels of p-AKT were also observed, which may be associated with the integrin-activated PI3K/AKT signaling pathway as, in addition to high expression of osteopontin and p-AKT, integrin β1 also showed increased levels [83]. The gene discussed is AKT1; the disease is thyroid gland follicular carcinoma.