Among these, some have been described as inducers of EMT in thyroid tumor progression, such as miR-146b, which is responsible for high TWIST levels, the inhibition of E-cadherin and the downregulation of PTEN expression, leading to enhanced thyroid tumor cell proliferation, migration and invasion, in addition to the inhibition of apoptosis, through the upregulation of the PI3K/AKT pathway [53]. Here, PIK3CA is linked to thyroid tumor.