According to the evidence that relates anaplastic development to differentiated thyroid cancer dedifferentiation and EMT upregulation [58], the miR-200 and miR-30 families, in addition to E-cadherin expression, were decreased, while ZEB1/2, SMAD2 and transforming growth factor beta receptor 1 (TGFBR1) were upregulated in anaplastic thyroid cancer, when compared to papillary and follicular thyroid cancer. Here, SMAD2 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.