Moreover, OPN can be related to EMT-associated RAS/MAPK activation through the expression of BRAF [76,89]; in papillary thyroid cancer, high OPN expression was associated with the BRAF V599E mutation along with advanced tumors and lymph node metastasis [76], and also with BRAF V600E mutated tumors [32,71]. The gene discussed is SPP1; the disease is thyroid gland papillary carcinoma.