Therefore, H3K4me3-mediated CD36 overexpression in Ob.HIR compared to Ob.LIR could be contributing to IR in these subjects; (6) F13A1 is also upregulated in Ob.HIR, whose absence induces in diet-induced mice “healthy obesity” [39]; (7) lack of DDRGK1 has been shown to cause ER stress (present in obesity) [40] and stress-induced apoptosis in cancer cells and hematopoietic cell lines [41]. The gene discussed is DDRGK1; the disease is obesity due to melanocortin 4 receptor deficiency.