Dongiovanni and Crudele et al. [208], demonstrated that the rs17618244 G > A variant in the β-Klotho (KLB) gene, encoding the hepatic co-receptor of FGFR4, dampened KLB plasma levels, leading to inflammation, ballooning, fibrosis and to the over-expression of genes involved in lipotoxicity in overweight NAFLD pediatric patients [208]. This evidence concerns the gene KLB and metabolic dysfunction-associated steatotic liver disease.