PNPLA3 and hepatocellular carcinoma: Then, Gellert-Kristensen and colleagues have assessed that a PRS including mutations in PNPLA3, TM6SF2 and HSD17B13 genes is associated with a 12-fold and 29-fold higher risk to develop cirrhosis and HCC, respectively, as it has been proven by examining 110,761 individuals from the Danish general population, 334,691 individuals from the UK Biobank, and a meta-analysis of the two studies combined [245].