PNPLA3 and hepatocellular carcinoma: Finally, the PNPLA3 p.I148M variant has been also reported to be associated with hepatic decompensation and liver-related death in a prospective study [74], with enhanced risk of fibrosis and HCC in patients affected by viral hepatitis or alcoholic liver disease (ALD) and with poor prognosis in patients affected by autoimmune hepatitis, regardless of steatosis [75,76,77].