PNPLA3 and metabolic dysfunction-associated steatotic liver disease: MBOAT7 variant was linked to elevated total body fat percentage, transaminases and C-reactive protein levels in pediatric individuals [120] and with enhanced ALT and more severe steatosis and fibrosis in children with NAFLD, showing a synergistic effect with PNPLA3 p.I148M, and TM6SF2 p.E167K variants on pediatric NAFLD risk [121], also confirmed in adult patients [34,35,122].