Likewise, the rs2228603 polymorphism in Neurocan, the rs12137855 variation in lysophospholipase-like 1 (LYPLAL1) and the rs10883437 SNP close to the carboxypeptidase n subunit 1 (CPN1) have been coupled to severe NAFLD [205,206]. The gene discussed is LYPLAL1; the disease is metabolic dysfunction-associated steatotic liver disease.