Moreover, Krawczyk and coworkers investigated the cumulative effect of PNPLA3, TM6SF2 and MBOAT7 genetic variants on the spectrum of NAFLD and they revealed that the rising number of risk alleles was associated with heavier AST and a trend for increased ALT and γ-glutamyl transferase (GGT) levels, which may mirror the severity of hepatic injury in NAFLD [122]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.