In addition, Schwartz and collaborators demonstrated that momelotinib, a drug used in clinical trials to treat myelofibrosis, may represent an effective modulator of PNPLA3 expression, yielding >80% reduction in PNPLA3 mRNA levels and hampering intracellular lipid content in human primary hepatocytes and stellate cells [60]. The gene discussed is PNPLA3; the disease is myelofibrosis.