In a study conducted in 384 Chinese NAFLD patients and 384 age- and gender-matched healthy controls, the number of risk alleles of PNPLA3 and TM6SF2 variants strongly correlated with the presence of NAFLD, showing an overall significative odd ratio (OR) of 1.64 which raised in additive manner, with an average increase in OR of 1.52 per additional risk allele [242]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.