SLC5A2 and type 2 diabetes mellitus: Based on gliflozin positive findings from three main CVOTs, as well as from trials investigating CV benefits in chronic HF and two large multinational studies, SGLT2-Is have been identified as a new class of compounds for the treatment of diabetic patients suffering from HF, a common and serious comorbidity of T2DM whose prevention represent a crucial therapeutic goal [21,22,23,135,136,137,138,139,140,141].