Naturally occurring shikonin analogues (deoxyshikonin, acetylshikonin, isobutyrylshikonin, β, β-dimethylacryloylshikonin, isovalerylshikonin, α-methyl-n-butylshikonin) induce necroptosis in resistant tumor cells overexpressing MDR1 and BCRP1 [322,352,353,354,355,356,357,358]. Here, ABCB1 is linked to neoplasm.