Tislelizumab, another anti-PD-1 antibody, engineered to have a high affinity and binding specificity for PD-1, will be tested in a phase III randomized, open-label, multicenter clinical trial (RATIONALE 301) as a first-line treatment in patients with unresectable HCC in comparison to sorafenib [89]. The gene discussed is PDCD1; the disease is hepatocellular carcinoma.