The platelet endothelial cell adhesion molecule, PECAM1; the vascular cellular adhesion molecule-1, VCAM1; the gene for human thrombospondin 3, an extracellular matrix glycoprotein which mediates interactions between cells and the extracellular matrix, THBS3; fibronectin 1, FN1; laminin subunit beta 1, LAMB1, and collagen type XII α1 chain, COL12A1, are all stimulators of tumour progression linked to increased metastasis, motility and invasion in different cancer types [38,39,40,41,42,43]. This evidence concerns the gene THBS3 and cancer.