Firstly, we demonstrated that the top 10 upregulated CRC-associated gene (DPEP1, KRT80, FABP6, NKD2, FOXQ1, CEMIP, ETV4, TESC, FUT1, and GAS2) transcripts were upregulated in CRC cell lines and public CRC datasets. The gene discussed is ETV4; the disease is colorectal carcinoma.