Treating the chondrosarcoma cells with MAPK inhibitors or siRNAs reversed WISP-3-promoted inhibition of miR-196a-5p expression, suggesting that WISP-3 may assist with VEGF-C production and LEC lymphangiogenesis by inhibiting miR-196a-5p synthesis via the MAPK signaling cascades. This evidence concerns the gene CCN6 and chondrosarcoma.