Similar effects were observed when the chondrosarcoma cell lines were transfected with ERK, JNK, or p38 siRNAs (Figure 2B,D, Figure 3B,D and Figure 4B,D), which substantially inhibited ERK, JNK, or p38 expression, respectively (Figure 2F, Figure 3F and Figure 4F). This evidence concerns the gene MAPK8 and chondrosarcoma.