From the mutations occurred frequently in the RING region from the graph of MARCH5 gene and encoded proteins (Figure 2B), we investigated the potential correlation between MARCH5 expression in breast cancer and several mutations common to breast cancer and showed the correlation between MARCH5 expression and each mutation, with PIK3CA being correlated (p = 0.00220) (Figure 2C). The gene discussed is MARCHF5; the disease is breast carcinoma.