Perhaps the strongest evidence for an EMT-like process in glioblastoma is the activity of classical EMT transcription factors and other well-described EMT-promoting pathways, such as ZEB1/ZEB2 [140,160,161,162,163], TWIST1 [164,165,166], WNT/β-catenin pathway [167,168] and SNAI2/SLUG [159,169] (Figure 1). The gene discussed is SNAI2; the disease is glioblastoma.