We found that the ACCN2 expression in healthy skin and in primary and metastatic melanoma lesions did not differ significantly, while the ACCN1, ACCN3, ACCN4, SCNN1A, and SCNN1G expression was dramatically down-regulated in primary and metastatic melanoma samples compared to normal skin biopsies (Figure 11a). This evidence concerns the gene ASIC2 and metastatic melanoma.