Indeed, analysis of expression of the genes ACCN2, ACCN1, ACCN3, ACCN4, SCNN1A, and SCNN1G coding the ASIC1a, ASIC2, ASIC3, ASIC4, α-ENaC, and γ-ENaC subunits, respectively, in mel P cells and Het-1A keratinocytes revealed that the ACCN2 and SCNN1G expression is significantly up-regulated in the cancer cells (Figure 3). Here, ASIC4 is linked to cancer.