Hyperbilirubinemia rats, which were induced by an intraperitoneal dose of UCB for 7 days (HB-7d) and 14 days (HB-14d), were further used to verify whether the increases in levels of bilirubin contributed to the upregulation of the brain LAT1 function and expression. The gene discussed is SLC7A5; the disease is Hyperbilirubinemia.