NOS2 and glioblastoma: In a phase I/II clinical trial, ParvOryx01, a rat H-1 parvovirus (H-1PV) for the treatment of recurrent glioblastoma patients, promoted an immunogenic TME, inducing accumulation of activated TAMs in CD40L-positive glioblastoma regions and up-regulation of cathepsin B and iNOS expression in TAMs [55].