As shown in Figure 7A–E, pretreatment with the JNK1/2 inhibitor (JNK-IN-8) and p38 inhibitor (SB203580) effectively reversed the expression of cleavage caspase-8, -9, and -3, and HO-1, compared with the magnolol-only-treated HSC-3 oral cancer cells. This evidence concerns the gene MAPK8 and lip and oral cavity carcinoma.