A recent study suggested that the increase in folate cycle activity via MTHFD2 also supplies UDP-GlcNAc to enable O-GlcNAcylation-mediated c-MYC stabilization, and thus promote PD-L1 transcription to limit CD8+ T cell cytotoxicity in HCC [100]. The gene discussed is MYC; the disease is hepatocellular carcinoma.