CAFs are ideal stromal partners to enable collective cancer cell invasion [120] via an intercellular physical force that is transmitted through a heterophilic adherens junction involving E-cadherin on the cancer cell membrane and N-cadherin on the CAF membrane, which can also exhibit the N-cadherin, afadin (AFDN; adherens junction formation factor), and mechanotransduction mediated CAF repolarization [119]. This evidence concerns the gene AFDN and cancer.