Decreased mRNA levels of fibrillin (FBN1), fibronectin (FN1), matrix-metalloproteinase 9 (MMP9) and vascular endothelial growth factor A (VEGFA) were identified in our microarray data analysis, and we have further validated their mRNA expression in RB cells in response to MYCN knockdown. The gene discussed is MMP9; the disease is retinoblastoma.