Particularly, the VDR-specific gene signature of late VR response (generated from Warwick et al. 2021 [14], Table S4) is further enriched in transcriptome of IDH1WT AML cells treated with exogenous 2-HG and in patients harboring IDH mutations (Figure 1C and Figure S1B). This evidence concerns the gene VDR and acute myeloid leukemia.