VDR and acute myeloid leukemia: Consistent with the enhanced activation of the VDR and ATRA pathways in HL60 IDH1WT+2HG (Figure 2C,D), 2-HG pre-treatment of IDH1WT and four parental AML cell lines elicited a higher sensitivity to differentiation induction by ATRA/VD combination (Figure 3E and Figure S4C,D).