PIK3CA and neoplasm: Indeed, they further generated PIK3CAH1047P variant in that mice model and observed that: (1) similar to ARID1A, PIK3CA mutation was not sufficient to initiate OCCC tumor formation, and (2) co-occurrence of both variants led to the rapid initiation of ovarian tumorigenesis, with peritoneal metastases observed in approximately 50% of the cases [40].