MGMT and metastatic malignant neoplasm in the lymph nodes: In HNSCC, specifically in laryngeal squamous cell carcinoma, the frequent hypermethylation of genes that are involved in cellular proliferation, apoptosis (DAPK, RASSF1A, RARbeta) and DNA repair (MGMT) was observed, and the hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT) was associated with lymph node metastasis [10].