CHEK2 and neoplasm: Considering the common variants shared by tumor fragments and plasma of women, we identified important gene variations in ACTR3B (C > T mutation), BRCA1 (T > A), CDC6 (C > T), CENPF (T > A), CHEK2 (T > C), EXO1, GATA3, and GRB7 (G > A), IGF2R (G > A and T > C), KIF2C (G > A), KRT5 (G > T and A > TG), MAP3K1 (C > T and CAA > -), MKI67 (T > C), MMP11 (T > C), MYBL2 (C > T), PMS2 (C > T), TP53 (T > C), TYMS (T > C), USH2A (G > A, G > T, and T > G) (Figure 7A).