TP53 and cancer: Somatic mutations in AKT1, PIK3CA, PTEN and TP53 genes are found at high frequency in human BC, representing 26.4% in PIK3CA, 24.7% in TP53, 3.8% in PTEN, and 2.8% in AKT1, according to the Somatic Mutations in Cancer Catalog (COSMIC) [13].