ACTA1 and cancer: Subsequently, Öhlund et al. [69] described different subtypes of cancer-associated fibroblasts (CAFs) in both mouse and human pancreatic cancer—high α-SMA expressing CAFs located adjacent to neoplastic cells (myofibroblastic CAFs; myCAFs) and low α-SMA-expressing cells at a distance from neoplastic cells, but with elevated IL-6 expression (inflammatory CAFs; iCAFs).